HLA-DRB1*11 is a strong risk factor for acquired thrombotic thrombocytopenic purpura in children

Bérangère S Joly; Pascale Loiseau; Michael Darmon; Thierry Leblanc; Hervé Chambost; Fanny Fouyssac; Vincent Guigonis; Jérôme Harambat; Alain Stepanian; Paul Coppo; Agnès Veyradier

doi:10.3324/haematol.2019.241968

HLA-DRB1*11 is a strong risk factor for acquired thrombotic thrombocytopenic purpura in children

Haematologica. 2020 Oct 1;105(10):e531. doi: 10.3324/haematol.2019.241968.

Authors

Affiliations

¹ AP-HP.Nord, hopital Lariboisiere, Université de Paris, Paris, France.
² AP-HP.Nord, hopital Saint-Louis, Université de Paris, Paris, France.
³ AP-HP.Nord, hopital Robert Debré, Université de Paris, Paris, France.
⁴ AP-HM, hopital de la Timone Enfants, Aix-Marseille Université, Marseille, France.
⁵ CHU de Nancy, hôpital de Brabois, Nancy, France.
⁶ CHU de Limoges, hôpital de la mère et de l'enfant, Limoges, France.
⁷ CHU de Bordeaux, hopital Pellegrin-Enfants, Université de Bordeaux, Bordeaux, France.
⁸ AP-HP.Sorbonne Université, hopital Saint-Antoine, Paris, France.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

ADAMTS13 Protein / genetics
Child
HLA-DQ beta-Chains
HLA-DRB1 Chains / genetics
Humans
Purpura, Thrombotic Thrombocytopenic* / epidemiology
Purpura, Thrombotic Thrombocytopenic* / genetics
Risk Factors

Substances

HLA-DQ beta-Chains
HLA-DRB1 Chains
ADAMTS13 Protein

Grants and funding

Funding. this study was partially supported by the National Plan for Rare Diseases of the French Ministry of Health (qualification of the French Reference Centre for Thrombotic Micro-Angiopathies) and the Programme Hospitalier Recherche Clinique AOM 05012 (DRCD Assistance Publique – Hôpitaux de Paris) and a grant from CSLBehring (AP-HP-2017-47-26).